| |
| |
|
Supplement Reference Guide |
|
|
|
Reviving Vitamin E Studies That Challenge Claims of Wonder Supplement Also Leave Openings
The last year hasn't been a good one for vitamin E. Once considered a wonder supplement, an inexpensive and harmless pill that might prevent heart disease, cancer and Alzheimer's, a flurry of recent clinical trials suggest it does none of those things. Some even suggest there is a small chance it could be harmful in higher doses. Yet while the oily little capsule apparently can't keep people alive longer, it refuses to die, in part because in nearly every one of the recent negative studies some caveat or contradictory finding creates a glimmer of hope. It also doesn't hurt that the dietary supplement industry continues to promote vitamin E and offers experts to refute some of new research. "It doesn't go away," said Edgar Miller, a vitamin E researcher and associate professor of medicine at Johns Hopkins University. "Why does it keep selling when there are so many of these negative studies?" The answer appears to be a combination of factors, including years of promising laboratory, animal and epidemiological studies; heavy promotion by the dietary supplement industry; and, more recently, contradictory findings within studies showing no overall benefit. The required daily amount is 22 IU (international units). Many recent clinical trials have ranged from 300 IU to 2,000 IU. Recent clinical trials of high-dose vitamin E have led some researchers to speculate that vitamin E in megadoses may increase the oxidation of LDL cholesterol, the bad kind. When cholesterol is oxidated, it contributes to coronary artery disease. There also is some concern that high amounts of vitamin E may displace other beneficial anti-oxidants from that average person's diet. Combining studies Consider these recent studies: In November, a vitamin E bombshell was dropped by Johns Hopkins University researchers at an American Heart Association meeting. They pooled 19 clinical trials of vitamin E involving 136,000 patients. In 11 of the high-dose trials (400 IU or more), the risk of dying from any cause increased 4%, compared with people taking placebos. Prior to that finding, vitamin E had been considered, at worst, harmless. "People take anti-oxidants because they want to live longer," said Miller, an associate professor of medicine. "What we showed is you don't live longer." However, the analysis also suggested that lower doses of vitamin E (less than 150 I.U. a day) were associated with about a 2% reduction in deaths. Researchers acknowledged several potential shortcomings in their study. For instance, they noted that several of the high-dose trials involved people with various chronic diseases and may not apply to healthy individuals. They also said the small size of several of the trials in the analysis and inconsistent reporting of health events prevented a detailed look at the effect of various doses of the vitamin. "It's a very flawed analysis," said Julie Buring, a professor of medicine at Harvard Medical School who recently presented her own vitamin E research. She also said the 4% increased risk of death was not "clinically meaningful" and could be a chance finding. Women's health study On March 7, Buring and other Harvard scientists presented their own vitamin E study at the American College of Cardiology annual meeting. Once again, the vitamin threw researchers a curve. Analyzing data from the Women's Health Study, a trial involving 40,000 women who got either 600 IU of vitamin E every other day or a placebo, researchers found that it provided no overall cardiovascular benefit such as reduction in heart attacks or strokes. However, an analysis of a subgroup of women over 65 found a 26% reduction in cardiovascular events. Buring said that although the finding was "intriguing," it was not supported by previous research. She added that it needs confirmation. Adding even more confusion, the study found a statistically significant 24% reduction in cardiovascular deaths among all the vitamin E users. Buring also questioned that finding because there was no overall reduction in strokes and heart attacks. She said it was possible that it was due to other cardiovascular causes such as arrhythmias or heart failure, but there was no reasonable biological explanation for that. "People should look at that further, but it could be chance," she said. Buring concluded that vitamin E was neither harmful nor beneficial in preventing cardiovascular disease. A surprise About a week after the Women's Health Study, another controversial vitamin E finding was presented. The study involved 9,500 people aged 55 and older with vascular disease or diabetes who were followed for an average of seven years. It found that 400 IU of vitamin E a day provided no protection against cancer or major vascular events such as heart attacks or strokes. In addition, the study found a disturbing 13% increase in heart failure cases and 21% increase in heart failure hospitalizations. That was the first time that vitamin E had been associated with an increased risk of heart failure, said lead author Eva Lonn, a professor of medicine at McMaster University in Hamilton, Ontario. "I am not convinced about the harm," Lonn added. Indeed, a recent small study of heart failure patients taking a cholesterol-lowering statin drug suggested that vitamin E actually increased the statin's ability to improve blood vessel function and lower inflammation. Lonn and the other researchers said a review of all heart failure events in large vitamin E clinical trials "is strongly recommended." Confounding the heart failure finding was what appeared to be a statistically significant 28% reduction in lung cancer cases, although in a secondary analysis of the data the benefit seemed to disappear. "The numbers are small," Lonn said. "We think it's a chance finding." The researchers noted that other larger vitamin E trials showed no lung cancer benefit. Alzheimer's research There still is some hope that vitamin E might help prevent Alzheimer's disease, although in May a clinical trial of 769 patients with mild cognitive impairment found it was of no benefit in delaying the progression to Alzheimer's. In that trial, the patients took a mega dose 2,000 IU a day for up to three years, according to the findings in the New England Journal of Medicine. Other vitamin E / Alzheimer's trials are ongoing. The anti-oxidant vitamin enthusiasm of the 1990s is being tempered by clinical trials, according to a JAMA editorial that accompanied the Women's Health Study results. "These hopes are now confined to modest expectations for specific disorders and there are concerns about adverse effects," the editorial said. Mike Freije from Health Shop
MORE RESOURCES:
|
|
|
|
RELATED ARTICLES
Supplements and Vitamins - Can They Enhance Your Weight Loss Goals? Nutritional supplements can play a key role in the health of children and adults. Many people feel that they don't get enough vitamins and minerals through their daily intake of food and, therefore, turn to supplements to fill in the gaps. What Good Is It To Stop Smoking If I Have Smoked For Years? I often hear people say that they have smoked for so long that they can't see what good it would do to quit now. So what is the big deal if you quit smoking? Will it do you any good or is it a pointless exercise in futility?My answer always is that the benefits of quitting smoking are enormous. Appreciating the Importance of Folic Acid Folic acid is actually just one of the many vitamins that make up the Vitamin B complex. Also known as folacin and folate, this indispensable nutrient serves the body in more ways than one. Researching Glyconutritionals (a.k.a. Glyconutrients)? The Greek word "Glyco" means, "Sugar". Most people think of sugar as being bad for you. The Worst $$$ I Ever Spent . . . Month after Month! "They", the "experts" all say how important vitamins are - how we don't get nearly enough of the nutrition we need in our every day diets because of all the processed food we eat these days.Well, I won't argue with that fact; seems like there's nothing wholesome and healthy out there anymore. Glyconutrients Will Be Revolutionary In Future Medicine - A Health Supplement (Part Two) PART TWOFor those of you that read my previous article about Glyconutrients, the Essential Sugars for Good Health, you will perhaps have realised that I am very passionate about them and the benefits that they can and have, already given to so many people around the world.I am passionate about them, not just because we can sell a product and make money, but, because we can help so many people to improve their health, wellbeing and lifestyle, and this makes us feel good too. Ephedra Ban Lifted April 14,2005 federal judge Tena Campbell of the federal district court in Salt Lake City Utah reversed the ban on ephedra.Ephedra is a herb used over 5000 years ago to treat several disorders,such as asthma and bronchitis. Fish Oils And A Plethora of Chronic Health Problems I recently heard of an older couple that eats salmon every day for breakfast. To my finicky palate that does not sound as appetizing as waffles. That Brilliant Vitamin: Vitamin B Perhaps you first read riboflavin at the back of a cereal box. Perhaps you first encountered folic acid from your first grade science teacher. Glyconutrients For You? Simply stated, the Greek word glyco refers to "sweet." Hence, a glyconutrient is a biochemical that contains a sugar molecule. Nitric Oxide Supplement Nitric oxide supplement has many benefits and there are many positive effects of nitric oxide. A free form gas produced by a breakdown of the amino acid Arginine, nitric oxide is produced by the body and the effects of nitric oxide supplement include nitric oxide supplement's ability to act as a cell communicator. Neugenisis Reviewed - Is It A Truly Effective HGH Releaser? Some say that the benefits of this all-natural HGH releaser far surpass any HGH product available currently. Taken nightly, Neugenisis is a special formula coated specifically to withstand the acids of the stomach in order to completly absorb into the bloodstream. Treatment of Heart Disease with Coenzyme Q10 Since its discovery in the late 1950â??s Coenzyme Q10 (CoQ10) has received much attention as a necessary compound for proper cellular function. It is the essential coenzyme necessary for the production of ATP (adenosine triphosphate) upon which all cellular functions depend. The History And Usefulness Of Coenzyme Q10 Throughout my childhood I was aware of the importance of eating well and taking my vitamins. But the science of dietary supplements has come a long way since those days. Ftiness Supplementation Fitness Supplement - what is it?The term "fitness supplement" is familiar to almost everyone nowadays. Fitness supplement is a supplement that is designed to help people who use it to achieve several results that include but are not limited to weight gain or weight loss, muscle building, adding vitamins or minerals to their diet, and many more. Is Ephedra a Miracle Cure? Americans are buzzing about the FDA's recent decision to reverse the ban on ephedra and ephedrine supplements in the United States. Known as the "world's oldest medicine," ephedra has been used for thousands of years for its variety of healing properties. How Selling Vitamins can Bring you Financial Freedom Most people are becoming more health conscious. Many of the baby boomers are looking for ways to look and feel younger. The Fountain Of Youth Aging, a steady declineThe History of the world is filled with stories of individuals trying to find eternal youth. Wealthy people going to private centers for magic elixirs. Achieving Youthful Healthy Skin with Vitamins A, C, and E We all want healthy skin. While the main reasons for pursuing healthy skin tend to be purely shallow and cosmetic in nature, healthy skin is beautiful and keeps us looking younger than our years and there are actually some practical health benefits to maintaining the good health for our skin. L-Glutathione, The Wonder Antioxidant A naturally occurring compound, L-Glutathione (Tathion,) has demonstrated that it is effective in fighting cancer, environmental poisons, and even cataracts. Sound like snake oil? Well, that is what I thought until I started doing research.
|
| home | site map | related links |
| © 2006 |
